Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 ;
Alternative:
Phospholipase C-zeta-1 (PLC-zeta-1) ;Phosphoinositide phospholipase C-zeta-1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Subcellular Location:
Nucleus
Cytoplasm
perinuclear region
Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronuclei at interphase following meiosis and mitosis.
Protein Attributes:
50:
MESQLHELAE | ARWFLSKVQD | DFRGGKINVE | ITHKLLEKLD | FPCHFAHVKH |
100:
IFKENDRQNQ | GRITIEEFRA | IYRCIVHREE | ITEIFNTYTE | NRKILSENSL |
150:
IEFLTQEQYE | MEIDHSDSVE | IINKYEPIEE | VKGERQMSIE | GFARYMFSSE |
200:
CLLFKENCKT | VYQDMNHPLS | DYFISSSHNT | YLISDQILGP | SDIWGYVSAL |
250:
VKGCRCLEID | CWDGSQNEPI | VYHGYTFTSK | LLFKTVVQAI | NKYAFVTSDY |
300:
PVVLSLENHC | SPGQQEVMAS | ILQSTFGDFL | LSDMLEEFPD | TLPSPEALKF |
350:
KILVKNRKVG | TLSETHERIG | TDKSGQVLEW | KEVIYEDGDE | DSGMDPETWD |
400:
VFLSRIKEER | EADPSTLSGI | AGVKKRKRKM | KIAMALSDLV | IYTKAEKFRN |
450:
FQYSRVYQQF | NETNSIGESR | ARKLSKLRVH | EFIFHTAAFI | TRVYPKMMRA |
500:
DSSNFNPQEF | WNVGCQMVAL | NFQTPGLPMD | LQNGKFLDNG | GSGYILKPDI |
550:
LRDTTLGFNP | NEPEYDDHPV | TLTIRIISGI | QLPVSSSSNT | PDIVVIIEVY |
600:
GVPNDHVKQQ | TRVVKNNAFS | PKWNETFTFL | IQVPELALIR | FVVETQQGLL |
647:
SGNELLGQYT | LPVLCMNKGY | RRVPLFSKSG | ANLEPSSLFI | YVWYFRE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Bovine
ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
strain :
C57BL/6J .
tissue :
Spermatid .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION
tissue :
Testis .
3.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Testis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-377
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;COFACTOR;INTERACTION WITH PTDINS(3)P AND PTDINS(5)P;DOMAIN
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DOMAIN;MUTAGENESIS OF ASP-210; LYS-299; LYS-301; ARG-376; LYS-377; ARG-378; LYS-379 AND LYS-381
11.
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,
Perry A.C.
Development134:3941-3952(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;OVEREXPRESSION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DOMAIN
13.
"Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish."
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Shikano T.
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Miyazaki S.
Biol. Reprod.78:1081-1090(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION